Alzheimers and Diabetes

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Alzheimer’s Disease could be Caused by a New Type 3 Diabetes

Researchers may see a connection between diabetes and Alzheimer’s disease. In fact, according to researchers, Alzheimer’s may be a third type of diabetes. The researchers examined insulin and the insulin receptor function in an area of the brain affected by Alzheimer’s disease.

The study compared the brain tissues of people who died at various stages of the disease.  Postmortem brain tissue of 45 patients with normal aging or different degrees of Alzheimer’s neurodegeneration, termed “Braak Stages” was examined.

The research conducted at the Rhode Island Hospital and Brown Medical School discovered that the insulin receptors dropped off significantly in the brain even in the early stages of the disease. The number of receptors continues to drop off as the disease progresses.

Alzheimer’s Disease could be Caused by a New Type 3 Diabetes

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Studies of post-mortem brains of women that suffered of Alzheimer’s disease showed they had significantly lower levels of estrogen in their brain tissue compared to women of similar age without the disorder.

First reported in this week’s online edition of the Proceedings of the National Academy of Sciences, the research shows that the lower level of estrogen can increase a women’s risk of having Alzheimer’s disease. It is more common for women to suffer of Alzheimer’s compared to men. One reason this is so is that women generally live longer, but the estrogen link may also contribute to a potential aid in preventing this debilitating disease.

Estrogen reduction alone does not insure that women will get Alzheimer’s, less than a quarter of women will get Alzheimer’s.

Alzheimers Disease caused by Low Estrogen in Brain

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Diabetics can cut Risk of Heart Attack and Stroke by increasing Insulin Injections

December 22nd 2005

Researchers have found that increasing the number in insulin injections per day will substantially reduce the risk of cardiovascular disease in Type 1 diabetes patients. Cardiovascular disease is one of the deadliest complications of the condition.

The risk of heart disease is 10 times greater in people with type 1 diabetes. The good news is that aggressively controlling blood sugar by increasing the number of injections a day will cut the risk of heart attack in half. Most diabetics will inject themselves once or twice a day. Aggressive control would mean five or six injections a day.

Dr. Saul M Genuth, chairman of a research project initiated in 1983 said "When you bring your blood glucose as close to normal as possible, that is what counts most,” reports Newsday. The first trial ended in 1993 and included 1,441 type 1 patients.

Diabetics can cut Risk of Heart Attack and Stroke by increasing Insulin Injections

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Exubera Inhaled Insulin Expected to be Available Soon for Diabetes Treatment
January 27th 2006


Exubera Inhaler
The Food and Drug Administration (FDA) approved the first inhaled form of insulin on Friday.  This method of intake is easier than injections and gives millions of adult diabetics an alternative to the older form of administering insulin.  Americans can expect to see this on the market by midyear.

Exubera, developed by Nektar Therapeutics, is a powder form of recombinant human insulin (rDNA) for treating adults with type 1 and type 2 diabetes.  According to an FDA press release, this is the first “insulin delivery option introduced since the discovery of insulin in the 1920s.”
Dr. Steven Galson, Director of the Center for Drug Evaluation and Research for the FDA said "It is our hope that the availability of inhaled insulin will offer patients more options to better control their blood sugars."

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[Jaded]

This is a wonderful wonderful thing if it is effective. My younger sis is a very brittle diabetic. She takes up to 10 shots a day to regulate her sugar levels. No one should have to endure that.

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(Best Syndication) Researchers in the UK say they have identified three new genes that predispose individuals to develop type-2 diabetes. Although poor diet and lack of exercise can increase the risk for developing type-2 diabetes, there are people that are genetically predisposed to developing the condition.

"This research helps us to understand that, for most people at least, an individual’s risk of developing diabetes as they get older is influenced by a number of genes, as well as by their environment," says Professor Mark McCarthy from the University of Oxford, one of the lead authors of the paper.

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Blood Test For Early Onset Of Alzheimer’s Disease



(Best Syndication) Researchers in California say they have developed a test for Alzheimer’s disease which can detect changes in certain protein cells in blood plasma. The proteins are used to convey messages between brain cells. Currently doctors determine if a patient has Alzheimer’s be excluding other causes for memory loss and cognitive decline.

It can be hard to determine whether a person has early Alzheimer’s or mild memory problems. The researchers at the Stanford University School of Medicine say the test is 90 percent accurate and can detect the disease 2 to 6 years before the onset of symptoms. The non-invasive test is not perfect, but neither is other clinical diagnosis for the disease. The only definitive diagnosis is by brain autopsy.

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[Crispy]

It's a freaky disease. I go to work and see these people who had brilliant minds... Harvard grads, pilots, chemists etc. and now they are reduced to infancy pretty much. Scares the shit out of me because I can't find anything to tie it all together. Healthwise they are all different.. very few are diabetic at our facility and some are even med-free.

I would love to do a study someday and have the time for it to be my "job". Nothing else but dig into the backgrounds, habits, families, everything I could think of to see if there is any tie at all to these people.

[Guitarras Reyes]

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Diabetes Can Be Forestalled By Diet And Exercise Changes



(Best Syndication News) There is some good news for people with a predisposition for developing diabetes, according to research published in the May 24th edition of Lancet. The current issue focuses on diabetes in preparation for the upcoming conference in the United States.

Chinese researchers conducted a 20 year study evaluated lifestyle changes rather pharmacological therapies. They evaluated 600 patients with glucose intolerance. In their follow-up they discovered that diet and fitness intervention for just 6 years can forestall diabetes. The lifestyle group had a 43 percent reduction in diabetes incidence.

Diabetes and Lifestyle Changes